Michael E Johnson
Professor Emeritus, University of Illinois at Chicago
Contact
Building & Room:
MBRB
Address:
900 S. Ashland Avenue
Office Phone:
Related Sites:
Research Interests Heading link
Structural biology of proteins and RNA; structure-based design of therapeutic agents using modern techniques of computer-aided drug design, combinatorial expansion, in silico screening of chemical libraries and related technologies. Modern biotechnology provides an enormous range of tools for the development of new therapeutic agents to treat infectious diseases and other human ailments.
Teaching and Supervision Heading link
Masters Thesis Research (BIOE 598), 1/11/2021 – 4/30/2021
Masters Thesis Research (BIOE 598), 8/24/2020 – 12/4/2020
Masters Thesis Research (BIOE 598), 1/13/2020 – 5/1/2020
Undergrad Res Exp MedChem&Pcog (PMMP 300), 1/13/2020 – 5/1/2020
Masters Thesis Research (BIOE 598), 8/26/2019 – 12/6/2019
Undergrad Resrch Med Chem&Pcog (PMMP 380), 8/26/2019 – 12/6/2019
Undergrad Res Exp MedChem&Pcog (PMMP 300), 1/14/2019 – 5/3/2019
Masters Thesis Research (BIOE 598), 1/14/2019 – 5/3/2019
Masters Thesis Research (BIOE 598), 8/27/2018 – 12/7/201
Selected Grants
Development of selective CSF1R inhibitors as novel asthma therapeutics, Chicago Biomedical Consortium, 7/1/2022 - Present, No Obligated Amount Set; No Anticipated Amount Set
Selective CSF1R inhibitors as novel asthma therapeutics, Chancellor Translational Research Initiative, 7/1/2022 - Present, No Obligated Amount Set; No Anticipated Amount Set
Inhaled high specificity colony stimulating factor 1 receptor (CSF1R) inhibitors as asthma therapeutics, UIC Proof of Concept Award, 7/1/2022 - Present, No Obligated Amount Set; No Anticipated Amount Set
Inhaled Colony Stimulating Factor 1 Receptor (CSF1R) Inhibitor for Asthma Therapy, UI Discovery Partners Institute, 8/1/2019 - 12/31/2021, Obligated Amount: $250000; Anticipated Amount: $250000
Novel Biofilm Inhibitors of Oral Streptococci, National Institutes of Health (National Institute of Dental and Craniofacial Research), 7/1/2019 - 6/30/2024, Obligated Amount: $414762; Anticipated Amount: $685330
Establish animal efficacy for highly active antimicrobial leads, Chicago Biomedical Consortium, 4/1/2019 - 3/31/2020, Obligated Amount: $30000; Anticipated Amount: $30000
Antibiotic Potentiation by Targeting of a Signal Transduction System, University of Maryland, 7/1/2017 - 2/28/2019, Obligated Amount: $310574; Anticipated Amount: $310574
Identification and Development of Small Molecules that Inhibit the VraSRT Operon, Which Maintains Oxacillin Resistance in Methicillin-Resistant S. Aureus (MRSA), Chicago Biomedical Consortium, 6/1/2016 - 11/30/2017, Obligated Amount: $20000; Anticipated Amount: $20000
Selected Publications
Rice, Amy J, Pesavento, Russell P, Ren, Jinhong, Youn, Isoo, Kwon, Youngjin, Ellepola, Kassapa, Che, Chun-Tao, Johnson, Michael E, Lee, Hyun. (2021). Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS. International Journal of Molecular Sciences, 22, (18), 9984. doi:10.3390/ijms22189984.
Austin, Julia R, Kirkpatrick, Brenna J, Rodríguez, Rocío Rivera, Johnson, Michael E, Lantvit, Daniel D, Burdette, Joanna E. (2020). Baicalein Is a Phytohormone that Signals Through the Progesterone and Glucocorticoid Receptors. Discover Oncology, 11, (2), 97-110. doi:10.1007/s12672-020-00382-6.
Ren, Yulin, Ribas, Hennrique T, Heath, Kimberly, Wu, Sijin, Ren, Jinhong, Shriwas, Pratik, Chen, Xiaozhuo, Johnson, Michael E, Cheng, Xiaolin, Burdette, Joanna E, Kinghorn, A Douglas. (2020). Na+/K+‑ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives. Journal of Natural Products, 83, (3), 638-648. doi:10.1021/acs.jnatprod.9b01060.
Johnson, Michael E, Fung, Leslie W-M. (2020). Structural approaches to pathway specific antimicrobial agents. Translational Research, 220, 114-121. doi:10.1016/j.trsl.2020.02.001.
Ren, Yulin, Tan, Qingwei, Heath, Kimberly, Wu, Sijin, Wilson, James R, Ren, Jinhong, Shriwas, Pratik, Yuan, Chunhua, Ngoc Ninh, Tran, Chai, Hee-Byung, Chen, Xiaozhuo, Soejarto, Djaja D, Johnson, Michael E, Cheng, Xiaolin, Burdette, Joanna E, Kinghorn, A Douglas. (2020). Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper. Bioorganic & Medicinal Chemistry, 28, (4), 115301. doi:10.1016/j.bmc.2019.115301.
Ren, Jinhong, Lee, Hyun, Kotak, Alpa, Johnson, Michael E. (2019). MD simulations reveal alternate conformations of the oxyanion hole in the Zika virus NS2B/NS3 protease. Proteins Structure Function and Bioinformatics, 88, (2), 345-354. doi:10.1002/prot.25809.
Lee, Hyun, Boyle-Vavra, Susan, Ren, Jinhong, Jarusiewicz, Jamie A, Sharma, Lalit Kumar, Hoagland, Daniel T, Yin, Shaohui, Zhu, Tian, Hevener, Kirk E, Ojeda, Isabel, Lee, Richard E, Daum, Robert S, Johnson, Michael E. (2019). Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus.. Antimicrobial Agents and Chemotherapy, 63, (9). doi:10.1128/aac.02593-18.
Ren, Jinhong, Ojeda, Isabel, Patel, Maulik, Johnson, Michael E, Lee, Hyun. (2019). Exploring small molecules with pan-genotypic inhibitory activities against hepatitis C virus NS3/4A serine protease. Bioorganic & Medicinal Chemistry Letters, 29, (16), 2349-2353. doi:10.1016/j.bmcl.2019.06.009.
Lee, Hyun, Ren, Jinhong, Pesavento, Russell P, Ojeda, Isabel, Rice, Amy J, Lv, Haining, Kwon, Youngjin, Johnson, Michael E. (2019). Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling. Bioorganic & Medicinal Chemistry, 27, (10), 1981-1989. doi:10.1016/j.bmc.2019.03.050.
Education
Degrees:
PhD, Northwestern University, United States, 1973
M.S., Northwestern University, United States, 1970
BSc, University of Wyoming, United States, 1968
Postgraduate Training:
Postdoctoral Associate, University of Pittsburgh, United States, 1975